头孢噻肟钠与奥硝唑配伍稳定性的实验研究

Stability of compatibility between cefotaxime and ornidazole sodium injection

目的:考察某医院常用药物头孢噻肟钠与奥硝唑氯化钠注射液配伍后的稳定性及变色原因。方法:采用紫外分光光度法测定两药配伍后的PH值,溶液颜色变化,测定吸收曲线变化及含量变化。结果:头孢噻肟钠在236nm,奥硝唑在319nm处有最大吸收;混合的液在40min时变为淡粉红色,在4h内,混合液的外观、pH值、峰形、含量均无明显变化。结论:头孢噻肟钠与奥硝唑氯化钠注射液配伍后可能会变色,临床应避免配伍。

Objective To investigate stability of compatility of ornidazole injection instilled after cefotaxime sodium for injection.Methods The contents and absorption curves of cefotaxime sodium and ornidazole sodium chloride injection after mix were determined by ultraviolet spectrophotometry.The PH of solution was assayed every 30 minutes by PH meter;the appearance of mixture was observed.Results The absorption peaks of cefotaxime sodium and ornidazole sodium chloride injection were at 236 nm and 319 nm,respectively.The mixtures turned into pale pink in 40min,but there were no evident changes in appearance,PH,content and absorption curves during 4 hours.Conclusion Ornidazole injection compatibility and cefotaxime sodium for injection clinical should avoid cefotaxime sodium and ornidazole and sodium chloride injection compatibility to prevent discoloration.