降纤酶佐治肺心病的疗效观察

Determination of the Effects of Defibrase as an Auxiliary Therapy on Cor Pulmonal

目的 观察降纤酶佐治慢性肺源性心脏病 (肺心病 )的临床疗效。 方法 84例肺心病患者随机分为治疗组和对照组各 4 2例。对照组给予常规治疗 ,治疗组在常规治疗的基础上加用降纤酶 ,第 1天 1 0 u,以后每天 5 u,加在生理盐水 1 0 0 ml中静脉滴注 ,连用 1 0天。治疗前后对两组患者进行血气分析以及血常规、肝和肾功能、血液流变学检测 ,并记录临床症状体征。 结果 治疗组显效率 66.7%、总有效率97.6% ,对照组显效率 3 5 .7%、总有效率 85 .7% ,两组比较有显著性差异 (P <0 .0 5 ) ;治疗组治疗后血气分析、血液流变学、血红蛋白 (Hb)等指标较治疗前明显改善 (P <0 .0 0 1 ) ;对照组治疗后除血气分析有显著性差异 (P <0 .0 1 )外 ,其余指标较治疗前无明显变化 (P >0 .0 5 ) ;治疗组治疗后上述指标较对照组更为显著改善 (P <0 .0 1 )。 结论 降纤酶佐治肺心病能迅速控制病情 ,疗效显著 。

Objective To observe the effect of defibrase as an auxiliary therapy on chronic pulmonary heart disease(cor pulmonale). Methods 84 patients with cor pulmonale were randomly allocated to control group(treated with conventional treatment) and treatment group(treated with defibrase and conventional treatment).To compare the changes of blood gas analysis,hemocytometry,liver and kidney function and hemorheology. Results The evident efficiency and total efficiency of treatment group was 66.7% and 97.6% respectively, they were 35.7% and 85.7% in control group,the difference has statistical significance between the two groups. Moreover,Most indexes were improved in treatment group as compared with control group. Conclusion Itis feasible treatment for cor pulmonale that defibrase as an auxiliary therapy.