摘要
Objective:To investigate the effect of apolipoprotein B(apoB) and E(apoE) genetic variations on lipid pro-file at baseline (before treatment),and also on the subsequent response to simvastatin therapy.Methods:Eighty-eight patients with hyperlipidemia were treated with simvastatin 5mg daily.The plasma lev-els of total cholesterol(TC) and low-density lipoprotein cholesterol(LDL-C),triglyceride(TG) and apoB were measured pre-treatment and at the end of the 4th,8th and 12th post-treatment week.Polymorphisms of apoB at XbaI locus and apoE were determined by restriction fragment length polymorphism(RFLP).Results:In all patients ,relative frequencies of X-allele and X+allele were 0.943 and 0.057 for apoB gene respectively.For apoE gene the relative frequency of ε2allele was determined as 0.182,ε3 as 0.580 and ε4as 0.238.The reduction in TC level was more prominent in patients carrying X-allele than in those with X+ allele following treatment(-23.9% vs.-13.6%,P<0.05).Compared with patients carrying ε3 or ε4 allele,those with ε 2 allele showed a significantly higher percentage in reduction of apoB level after treatment(P<0.05).Conclusion:The relative frequency of apoB X+allele is high in patients with hyperlipidemia,in whom the TC-lowering efficacy is decreased following treatment of simvastatin.The relative frequencies of ε 2 and ε 4are also high in hyperlipidemic patients,and the ε2 allele is associated with reduction in apoB level during lipid-regulating therapy.
