甲泼尼松龙与布地奈德分别治疗64例慢性阻塞性肺疾病急性加重期的疗效比较

The Clinical Effect Comparison of Methylprednisolone and Budesonide on Acute Exacerbation of Chronic Obstructive Pulmonary Disease respectively Comparison

目的:探讨甲泼尼松龙与布地奈德分别治疗慢性阻塞性肺疾病急性加重期的疗效差异。方法:选择128例慢性阻塞性肺疾病急性加重期患者,随机分为观察组和对照组各64例。两组均给予常规治疗,观察组同时给予布地奈德治疗,对照组给予甲泼尼松龙治疗,观察两组治疗效果。结果:观察组治疗后的第一秒用力呼气量、动脉氧分压和二氧化碳分压、临床症状评分分别与对照组治疗后比较,差异无统计学意义(P>0.05)。两组均无严重不良反应发生。结论:布地奈德吸入治疗能够改善慢性阻塞性肺疾病急性加重期患者的临床症状和体征,其疗效和甲泼尼松龙近似,值得借鉴。

Objective: To explore the clinical effect comparison of methylprednisolone and budesonide on acute exacerbation of chronic obstructive pulmonary disease respectively comparison. Methods: 128 patients with acute exacerbations of chronic obstructive pulmonary disease were selected and randomly divided into observation group and control group. Two groups were given conventional treatment,the observation group given budesonide,the control group was given methylprednisolone. the therapeutic effect in two groups was observed. Results: The first second forced expiratory volume,arterial partial pressure of oxygen and carbon dioxide,clinical symptom scores in the observation after treatment compared with those in the control group after treatment,there was no significant difference( P > 0. 05). There were no serious adverse reactions in two groups. Conclusion: Budesonide inhalation therapy can improve the clinical symptoms and signs of chronic obstructive pulmonary disease in patients with acute exacerbation of therapy,the curative effect is similar with those of the methylprednisolone.