重质芳烃对雄性小鼠生殖细胞遗传效应的研究

Studies on genetic effects of heavyweight aromatic hydrocarbon on germ cells in male mice

目的 探讨重质芳烃对雄性小鼠生殖细胞遗传效应。方法 通过小鼠精子畸形实验和小鼠睾丸染色体畸变实验进行遗传毒性研究。结果 在重质芳烃高剂量组 ,小鼠精子畸形率、睾丸染色体结构畸变率、性染色体早分离率、常染色体分离率与阴性对照组比较 ,差异呈高度显著性。结论 重质芳烃对雄性小鼠生殖细胞有一定的遗传毒性 ,应重视重质芳烃对接触人群的潜在危害 。

Objective To study genetic effects of heavyweight aromatic hydrocarbon(HAH)on germ cells in male mice.Meth-ods Sperm deformity test and testes chromosome aberration test were used in the studies.Results Higher rates of sperm deformity,testes aberration,early separation of sex chromosome and separation of autosome were observed in male mice exposed to high dose of HAH with highly statistical significance,as compared with those in control group.Conclusions HAH had certain genotoxicity on germ cells in male mice.Importance should be attached to potential hazard caused by HAH and labor hygienic protection and health monitor-ing should be strengthened for those exposed to HAH.