重度牙周炎患者治疗前后血清TNF-α水平的变化

Change of Circulating TNF-αin Patients with Advanced Periodontitis Before and After Periodontal Initial Therapy

目的探讨牙周基础治疗对牙周炎患者血清TNF-α水平的影响。方法比较重度牙周炎患者牙周基础治疗前及治疗后4～6周的牙龈出血指数、探诊深度和血清TNF-α浓度。结果牙周炎患者血清TNF-α的浓度显著高于对照者(P<0.01);经牙周基础治疗后,患者牙龈出血指数、探诊深度和血清TNF-α浓度均显著下降(P<0.01)。结论牙周炎患者可能通过血清TNF-α浓度升高而对全身健康造成不良影响;预防和治疗牙周炎对于维护全身健康,防治系统性疾病具有重要意义。

Objective To investigate the effect of periodontal initial therapy on circulating tumor necrosis factor-alpha(TNF-α)in patients with periodontitis.Methods Patients with advanced periodontitis were selected.Sulcus bleeding index(SBI),probing depth(PD),and circulating TNF-αconcentration were assessed respectively before and4～6weeks after periodontal initial therapy.Results The level of circulating TNF-αin patients with periodontitis was significantly higher than that in healthy control subjects(P<0.01).After periodontal initial therapy,SBI,PD and circulating TNF-αconcentration were reduced significantly(P<0.01)in patients with periodontitis.Conclusion Periodontitis may have profound effects on systemic health through the elevation of circulating TNF-α.Prevention and treatment of periodontitis should be important in maintaining systemic health.<