几种中草药及绿茶对B(a)P和NNK的抗诱变作用

STUDY ON ANTIMUTAGENICITY OF CHINESE HERBAL MEDICINE AND GREEN TEA TO BENZOAPYRENE AND NNK

目的 :探讨绿茶、茶多酚、半枝莲、白花蛇舌草及犀黄丸等的水溶性提取物对苯并芘[B(a)P]和4_甲基亚硝胺基_1_(3_吡啶基)_1_丁酮(NNK)的抗诱变作用。 方法 :采用沙门氏菌回变试验(Ames试验)。 结果 :除各受试物的最小剂量组外 ,其它浓度的绿茶、茶多酚、半枝莲、白花蛇舌草及犀黄丸等均具有明显的抑制B(a)P和NNK诱发TA98 和TA100 回复突变的作用。经统计学处理 ,各试验组与对照组比较有显著性差异(P<0.01)。 结论 :受试的中草药和绿茶对B(a)P和NNK均有抗突变作用 。

Purpose: To investigate the antimutagenicity of water extract of green tea, tea polyphenol, Scutellaria barbata D. Don, Hedyotis diffusa wildi and Xihuangwan to benzoapyrene and 4_methylnitrosamino_1_(3_pyridy)_1_butanone(NNK). Methods: The A mes test was used in this study. Results: Except the lowest dosage group, all the other dosage groups of green tea, te a polyphenol, Scutellaria barbate,Hedyotis diffusa wildi and Xihua ngwan inhibited the reverse mutation of TA 98 and TA 100 induc ed by B(a)P and NNK significantly(P<0.01). Conclusion: The teste d Chinese herbal medicines and green tea have antimutagenicity to B(a)P and NNK, and there is a dose_effect relationship.