粒-巨噬细胞集落刺激因子治疗血液病化疗所致的口腔黏膜炎的研究

Study of granulocyte-macrophage colony stimulating factor treatment on hematological patients with chemotherapy induced oral mucositis

目的 :探讨粒 -巨噬细胞集落因子 (GM—CSF)悬液应用于血液病化疗所致口腔黏膜炎 (OM )的效果 ,并与常规使用的口腔药膜比较。方法 :随机将 10 0例血液病化疗后发生OM的患者分为两组 ,分别用CM—CSF悬液局涂或予口腔药膜外贴 ,比较两组不同部位和程度的OM的愈合情况。结果 :试验组与对照组在相同部位的Ⅰ、Ⅱ、Ⅲ度OM的愈合时间上存在显著的差异 (P <0 .0 1) ,对Ⅳ度OM的愈合时间也有差异 (P <0 .0 5 )。两组不同部位的愈合时间顺序无差异 (P >0 .0 5 ) ,唇部OM愈合最早 ,硬腭部OM愈合最晚。结论 :GM—CSF悬液对不同口腔部位Ⅰ、Ⅱ、Ⅲ及IV度化疗所致的OM的作用明显优于常规的口腔药膜治疗。

Objectives: To evaluate the efficacy of granulocyte-macrophage colony stimulating factor (GM-CSF) treatment on hematological patients with chemotherapy-induced oral mucositis and compare with conventional treatment of oral drug membrane. Methods: Randomly divided 100 patients into two groups and treated with GM-CSF mixture or drug membrane. Statistically compared the efficacy of the two groups. Results: There were significant differences between two treatment groups for OM in same location with severity ofⅠ,Ⅱ,Ⅲ (P<0.01) and Ⅳ degrees (P<0.05).There were no significant differences between two groups concerning their OM healing time sequence in different locations (P>0.05). OM in labial area healed fast, while OM in hard palatal area healed slowly. Conclusion: GM-CSF is better than conventional drug membrane for treating chemotherapy induced oral mucositis with severity ofⅠ,Ⅱ,Ⅲ and Ⅳ degree.