肿瘤基因治疗的靶向性策略

Strategies of tumor-targeted gene therapy

肿瘤基因治疗的靶向性问题直接关系到治疗的成败。这种靶向性的策略包括目的基因对肿瘤细胞的靶向转移 ,目的基因在肿瘤细胞中的特异表达 ,以及基因修饰细胞分泌的肿瘤靶向治疗分子。对现有病毒或非病毒载体进行改造 ,由与载体融合的抗体或配体与肿瘤表面抗原或受体的相互作用可以实现目的基因的靶向转移 ;肿瘤或组织特异性调控元件的应用 ,以及一些物化。

Targeting of tumor cells is crucial for gene therapy of malignant diseases.This can be achieved by tumor targeted gene transfer or tumor specific gene expression, as well as secretion of tumor targeted therapeutic molecules by autologous normal cells.Tumor targeted gene transfer is mediated by the recognition of a class of tumor specific antigens or receptors by corresponding vector fused antibodies or ligands, while therapeutic genes can be selectively expressed in tumor cells under the control of tumor or tissue specific promoters or enhancers, as well as the induction of certain physical, chemical or physiological factors.