摘要
采用复合乳液 溶剂挥发法制得明胶 聚乳酸载五氟脲嘧啶 (5 Fu)微球 ,以混合型乳化剂Tween 80∶Span 80 =5∶1 作为初乳乳化剂 ,O 羧甲基壳聚糖作为复乳乳化剂 ,考察了明胶 聚乳酸载药微球的制备条件对微球的成球性、药物包封率及体外释药的影响。结果表明乳化剂的选择、内部水相药物浓度和PLA分子量等均对载药微球的结构与性能产生影响 ,经优化条件得到了成球性和体外释放都比较好的载药微球。
PLA-Gelatin nanospheres loaded with 5 - fluorouracil were prepared by solvent evaporation with the compound latex. The products were characterized by XPS, SEM, drug loading rate, and drug release behavior in vitro. Morphological studies revealed that nanospheres were spherical in shape with smooth surfaces. Physiochemical characteristics of the nanospheres were affected by the formulation parameters. The diameter of the prepared nanospheres ranged from 400 - 600nm. The optimal initial latex was identified to be Tween-80: Span-80 = 5: 1. The carboxymethylated chitosan, as secondary latex, was found to serve better than chitosan. The drug encapsulation efficiency and in vitro drug release behavior were improved by changing the drug concentration in the internal water phase, as well as the increase in molecular weight of the hydrophilic polymers in continuous phase.
出处
《中国生物医学工程学报》
EI
CAS
CSCD
北大核心
2003年第2期178-182,共5页
Chinese Journal of Biomedical Engineering
基金
国家重大基础研究 (973 )项目
前期研究专项基金资助项目 (P2 2 0 0 10 4)
天津市科委重点基金资助项目 (0 13 616611)
关键词
明胶-聚乳酸
载药
纳米微球
制备
体外释药
研究
Encapsulation
Evaporation
Hydrophilicity
Scanning electron microscopy
Solvents
Tumors
X ray diffraction analysis