浓缩红细胞输注抢救贫血性心脏病心力衰竭疗效分析

Research into infusion of concentrated red cell into treatment of heart failure in anemic heart disease

目的 改善贫血性心脏病心力衰竭患者生活质量 ,降低病死率 ,探讨最佳治疗方法。方法 对 42例贫血性心脏病心力衰竭患者采用少量多次输注浓缩红细胞 ,并与 40例输全血者对照。结果 心功能 (NYHA)进步 1级以上治疗组90 5 % ,显著高于对照组的 45 % (P <0 0 1) ;病死率治疗组 9 5 % ,显著低于对照组的 5 5 % (P <0 0 1) ;每搏输出量 (SV)治疗组治疗前后分别为 (81 1± 13 6)mL与 (76 7± 11 2 )mL(P >0 0 5 ) ,对照组分别为 (83 2± 12 3 )mL与 (78 2± 12 8)mL(P >0 0 5 ) ;左室射血分数 (LVEF)治疗组治疗前后分别为 (73± 15 ) %与 (71± 12 ) % (P >0 0 5 ) ;对照组分别为 (75± 13 ) %与 (72±13 ) % (P >0 0 5 )。结论 浓缩红细胞输注可改善贫血性心脏病患者心功能 ,降低病死率 ;LVEF不是判断本型心力衰竭转归的敏感指标 ,而血红蛋白、心率、NYHA分级则可客观地反应心功能状况 ;浓缩红细胞输注是治疗贫血性心脏病心衰安全、有效的方法 。

Objective To reduce the mortality and improve the quality of the patient's life in patients with anemic heart disease and heart failure.Methods 42 patients received the infusion of concentrated red cell by the methods of low dosage and long times.In comparison with this,40 patients received the infusion of whole blood cells.Results There were 90.5% patients in treatment group and 45% patients in control group whose heart function has been remarkedly improved 1 scale (P<0.01);The mortality in the former was 9.5% and 55% in the latter(P<0.01);The heart rate before and after treatment in treatment group are 102±13 versus 88±15 beats perminute in coutrol (P<0.01);The SV before and after treatment were 81.1±13.6 versus 76.7±11.2 in treatment group and 83.2±12.3 versus 78.2±12.8 in control, respectively. LVEF were (73±15)% versus (71±12)%(P>0.05) in treatment group and (75±13)% versus (72±13)% in control(P>0.05),respectively.Conclusion The infusion of concentrated red cell could improve the heart function and reduce the mortality of the patients who suffered from the anemic heart disease and heart failure.