摘要
本文报道31例煤矽肺病人血清和支气管肺泡灌洗液脂质过氧化物(LPO)的检测分析。结果表明煤矽肺病人LPO含量非常显著地高于正常人和肺癌病人,并且血清LPO含量随煤矽肺病人年龄和从事煤矿工作工龄的增长而升高。证明在矽肺引发病理过程中脂质过氧化作用增强、丙二醛蓄积。该作用与肺纤维化程度相关,也提示LPO参与矽肺的发生和发展。
This article presents the observation on the content of serum and BALF lipid peroxide (LPO) in 31 cases of coalsilicosis. The results showed that the content of LPO in these patients was siginficantly higher than those in healthy subjects and the patients with lung cancer, and that the content of LPO in serum increased as the patients' age and the length of coal—working increased. Based on above observation we concluded that lipid peroxidation strengthened and MDA in lung tissue and blood accumulated in the course of coal—silicosis and that LPO played a role in pathogenesis of coal—silicosis.
