神经生长因子在变应性鼻炎病人鼻黏膜中的表达

Expression of nerve growth factor in the nasal mucosa of allergic rhinitis patients

目的 进一步探讨神经生长因子(nerve growth factor,NGF)在变应性鼻炎发病中的作用。方法采用酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)方法对30例变应性鼻炎病人鼻黏膜组织中NGF的含量进行检测,以10例正常鼻黏膜组织作对照。结果 变应性鼻炎组鼻黏膜组织中NGF的含量为(6.03±1.53)ng/g湿重(n=30),明显高于对照组鼻黏膜组织中NGF的含量(3.43±1.19)ng/g湿重(n=10),两组差异有统计学意义(P<0.001)。结论 NGF与变应性鼻炎的发生有着密切联系。

Objective To further explore the functions of nerve growth factor (NGF) in the allergic rhinitis. Methods The NGF content in the nasal mucosa of 30 allergic rhinitis patients was measured by enzyme - linked immunosorbent assay (ELISA). Results The NGF content in the nasal mucosa of allergic rhinitis patients was (6.03 ± 1.53) ng/g wet weight (n= 30), which was significantly increased compared with that in the control group (3.43 ± 1.19) ng/g wet weight (n= 10, P <0.001). Conclusion The NGF plays an important role in the development of allergic rhinitis.