摘要
目的 检测p2 1WAF1蛋白在喉癌中的表达水平 ,研究其表达与临床、病理参数的关系 ,探讨p2 1WAF1在喉癌发生发展过程中的作用。方法 选取喉癌患者 3 0例 ,另选声带息肉患者 3 0例及正常喉组织 6例作为对照 ,采用免疫组织化学方法 (S -P法 )检测其p2 1WAF1的表达。结果 p2 1WAF1蛋白在喉癌、声带息肉中的阳性率分别为 2 7% ( 8/3 0 )及 5 3 %( 16/3 0 )。正常喉组织均为阴性。喉癌中p2 1WAF1蛋白表达与组织分化呈正相关 ,分化越高 ,阳性率越高。结论 p2
Objective To examine the expression of p21 WAF1 protein in laryngeal carcinoma and investigate its role in the progression of laryngeal carcinoma. Methods 30 history confirmed specimens of primary laryngeal carcinoma were subjected to immunohistochemical analysis of p21 WAF1 protein. Thirty cases of vocal cord polyps and 6 cases of normal laryngeal epidermal tissue were selected as control. Results The positive rate of p21 WAF1 in laryngeal carcinoma and vocal polyps was 27%( 8/30 ) and 53%( 16/30 ). No positive expression was found in normal laryngeal tissue. The expression of p21 WAF1 showed a positive correlation with histological differentiation in laryngeal carcinoma. Conclusion p21 WAF1 is an important factor in the occurrence and development of laryngeal carcinoma.
出处
《广东医学》
CAS
CSCD
2003年第5期474-476,共3页
Guangdong Medical Journal
基金
国务院侨务办公室基金资助项目 [编号 :(1 998) 1 75 - 2 3]
