涎腺粘膜相关淋巴组织淋巴瘤临床病理分析及治疗

Treatment and Clinicopathologic Analysis of Mucosa-associated Lymphoid Tissue Lymphoma of the Salivary Glands

目的 通过对粘膜相关淋巴组织淋巴瘤的临床病理分析,以期加深对该病的认识。方法 对本院口腔颌面外科5年来收治的4例涎腺粘膜相关淋巴组织淋巴瘤的临床病理资料及治疗预后情况进行分析。结果 4例患者临床分期分别为ⅢA期(1例)和ⅠE期(3例),分别给予单纯切除涎腺原发灶、切除涎腺原发灶并术后局部放疗、单纯联合化疗(CHOP方案)及切除涎腺原发灶并术后局部放疗和联合化疗(CHOP方案)。所有病例病情得到完全缓解。结论 涎腺粘膜相关淋巴组织淋巴瘤多为无痛性过程,发展缓慢,长期局限。多种治疗均可完全缓解病情,达到无瘤生存状态,预后较好。

Objective To further understanding of lymphoma of salivary gland through clinicopathologic analysis. Methods Clinical findings, pathologic features, clinical staging, therapy and prognosis of 4 cases were reviewed and clinically analysed. Results Different treatment were received by the 4 patients, one had stage ⅢA disease and three had stage ⅠE disease. All patients got their illness completely remitted. Conclusion Mucosa-associated lymphoid tissue lymphoma of the salivary glands is an indolent disease. Different treatments can all result in prolonged remission, and it has better outcome than other NHL.