尿激酶静脉溶栓与其它药物治疗急性脑梗死对照研究的Meta分析

Meta-analysis of comparative study in treatment of acute cerebral infarction between intra-venous thrombolysis with urokinase and other drugs

①目的 了解尿激酶静脉溶栓与其它药物治疗急性脑梗死(ACI)的疗效、②方法 应用Meta分析对10项研究尿激酶静脉溶栓与其它药物治疗ACI的效果进行同质性检验和合并效应量的估计。③结果 同质性检验:x^2=4.2964,自由度为9,P>0.05。合并效应量的估计:OR_(合并)=3.7239,OR_(合并)95％可信区间为2.63～5.26。OR_(合并)的检验:x^2=55.5,P<0.001。④结论 尿激酶静脉溶栓治疗ACI的疗效显著,优于目前常用药物。

Objective To explore the difference of efficacy between intra-venous thrombolysis with urokinase and other drugs in treatment of acute cerebral infarction. Methods The efficacies of intra-venous thrombolysis with urokinase or other drugs in treatment of acute cerebral infarction were analyzed by meta-analysis in homogeneity test and combined test in 10 studies. Results (1)Homogeneity test shows that the cited studies are homogeneous with X2 = 4. 2964,P>0. 05;and (2) in combined test,the combined OR = 3. 7239 and its 95% confidence interval was in 2. 63 ~ 5. 26(X2 = 55. 5,P<10. 001). Conclusion The efficacy of intra-venous thrombolysis with urokinase for acute cerebral infarction is significantly superior to those at present used medicines.