慢性乙型肝炎患者远期生存质量研究

Long-term health-related quality of life in chronic hepatitis B patients

目的 对慢性乙型肝炎患者远期生存质量进行研究,为其预后判断,药物疗效的分析及药品经济学评估提供依据。 方法 采用补充修订的SF-36健康相关生存质量量表调查101例6～l 8年前经肝穿活组织检查诊断的慢性乙型肝炎和105例门诊体检的普通人群。 结果 慢性乙型肝炎患者在生理机能、生理职能、总体健康、精神健康、肝病特有症状5个方面的远期生存质量低于普通人群,差异有显著性(μ≥2.10,P<0.05)。 结论 慢性乙型肝炎患者远期生存质量差。

Objective To evaluate their long-term outcome and the efficacy and economic significance of antiviral drugs by investigating the long-term health-related quality of life (HQL) in chronic hepatitis B (CHB) patients. Methods The HQL of 101 CHB patients with biopsy-proven 6-18 years ago and 105 persons of general population as control was studied with revised SF-36 questionnaire. Results The HQL in CHB patients was lower than that in general population in physical functioning, role physical, general health, mental health, and specific symptoms (μ≥ 2.10, P < 0.05). Conclusion The long-term HQL in chronic hepatitis B patients is poor.