变应性鼻炎患者血浆P-选择素的测定及其意义

Determination and significance of plasma P-selectin in patients with allergic rhinitis

目的 :探讨变应性鼻炎 (AR)患者血浆P 选择素 (P selectin)在AR发病中的意义。 方法 :采用ELISA法对 5 8例AR患者 (AR组 )和 30例正常健康者 (对照组 )血浆P 选择素水平进行检测。结果 :AR组血浆P 选择素水平 (5 8.76± 16 .5 7)明显高于对照组 (2 1.4 3± 7.86 ) ,差异有极显著性意义 (P <0 .0 1)。结论 :血浆P 选择素水平与AR有一定关系 ,提示血浆P 选择素在AR的发病机制中可能起重要作用。

Objective:To study the level of plasma P-selectin in patients with allergic rhinitis(AR) and to investigate its significance.Method:The concentration of P-selectin in plasma of 58 patients with AR and 30 normal volunteers were detected with ELISA method.Result:The levels of plasma P-selectin in AR group was higher than that in normal control group(P< 0.01).Conclusion:There is relationship beween the level of P-selectin in plasma and AR. It suggests that the P-selectin may play an important role in the pathogenesis of AR.