呼吸道真菌感染致顽固性哮喘20例分析

Refractory asthma due to fungas infection in respiratory tract:An analysis of 20 cases

目的 探讨顽固性哮喘的诱发原因。方法 对 2 0例呼吸道真菌感染致顽固性哮喘进行回顾性分析。结果 所有病例均应用广谱抗生素、大量激素及解痉剂未能控制哮喘 ,且类固醇抵抗型哮喘可除外 ,病原菌主要以白色念珠菌属为主 (40 % )。早期诊断仍困难 ,易延误病情 ,以致重症哮喘易致呼吸衰竭。结论 肺部真菌感染是多种疾病继发感染的重要原因 ,其临床表现特异性少 ,病死率高 ,发病呈上升趋势 ;临床应高度重视真菌感染导致的重症哮喘。

Objective To explore the induced reasons of refractory asthma.Methods Twenty cases of stubborn asthma due to fungus infection in respiratory tract were analysed retrospectively.Results All cases were treated with borad spectrum antibiotics,large quantity of hormone and antispastic,which didn't control asthma except for steroid resistent type of asthma.The pathogen was mainly candida abbicans(40%).Early diagnosis was still difficult.The disease might resutt in severe asthma and respiratory failure.Conclusion Pulmonary fungus infection is the important cause of the complications of many kind of diseases.The clinical manifestations are less speciality,high mortality,raising mobidity.The causes of severe asthma,especially the fungal infection,should be payed more attention.