肝肾综合征病人血清促红细胞生成素水平的测定及其临床意义

Detection of serum erythropoietin level in patients with hepatorenal syndrome and its clinic significance

目的 研究肝肾综合征 (HRS)病人及其肾功能恢复后的血清促红细胞生成素 (EPO)水平的变化 ,了解血清EPO水平变化在HRS中的临床意义。方法 采用放射免疫分析法检测 11例HRS病人血清EPO水平 ,经内科治疗使肾功能恢复后再检测血清EPO水平 ,进行自身配对比较分析。结果 HRS病人血清EPO水平明显高于正常对照组 (P <0 0 1) ,肾功能恢复后血清EPO水平明显低于治疗前 (P <0 0 1) ,但此时血清EPO水平仍明显高于正常对照组 (P <0 0 1)。结论 HRS病人肾脏的低灌注造成肾脏缺血、缺氧 ,使肾脏分泌EPO明显增加。肝硬变失代偿期时若血清EPO水平较前显著升高 ,应考虑HRS发生的可能或将要发生HRS。

Objective To study the changes of the serum erythropoietin(EPO) levels in patients with hepatorenal syndrome(HRS) and its clinic significance in HRS.Methods The serum EPO level was detected with radio immunity analysis technique in 11 patients with HRS.After treatment and recovering of renal function,the level of serum EPO was detected again.The results were analyzed and compared with self matched pairs.Results The serum EPO level in patients with HRS were significantly higher than that in healthy control group(P<0.01).The serum EPO level after recovering were significanty lower than that before treatment(P<0.01),but the serum EPO level were still significantly higher than that in the healthy control group(P<0.01).Conclusion The renal hypoperfusion in patients with HRS leads to ischemia and anoxia,and obviously increases the kidney excret EPO.In the period of failure compensation of liver cirrhosis,if the serum EPO level has a remarkably increase,the possibility of HRS should be considered.