功能性消化不良患者胃排空障碍与神经降压素关系的研究

Relationship between gastric emptying and neurotensin in functional dyspepsia patients

目的 探讨功能性消化不良 (FD)患者胃排空障碍与神经降压素的关系。方法 对 5 4例FD患者进行胃排空检查 ,根据结果将其分为胃排空延缓FD组 (FDD组 )和胃排空正常FD组 (FDN组 ) ,17例正常人作为对照组。采用放免法测定受试者血浆 (空腹和餐后 )、胃窦和十二指肠粘膜组织的神经降压素 (Neurotensin ,NT)含量。结果 FDD组空腹和餐后血浆、胃窦和十二指肠粘膜组织的NT含量均明显高于正常对照组及FDN组。各组试餐前后血浆NT增幅无显著性差异。FDN组空腹和餐后血浆、胃窦和十二指肠粘膜组织NT含量与正常对照组无显著性差异。结论 FD患者胃排空障碍与NT密切相关。

Objective To study the relationship between gastric emptying dysfunction and neurotensin(NT) in functional dyspepsia(FD) patients. Methods Gastric emptying function in 54 FD patients was measured with solid radioopaque markers. Patients were divided into two groups according to the results, one of which with delayed gastric emptying and the other with normal gastric emptying. Seventeen healthy volunteers served as normal control group. The NT levels in plasma (fasting and postprandial) and the mucosa of gastric antrum and descending portion of duodenum were measured by radioimmunoassay(RIA). Results The NT levels in fasting and postprandial plasma and the mucosa of gastric antrum and descending portion of duodenum in FD group with delayed gastric emptying were significantly higher than those in FD group with normal gastric emptying and in normal control group. The three groups did not differ significantly in incremental extent of plasma NT after test meal. The NT levels in fasting and postprandial plasma and the mucosa of gastric antrum and descending portion of duodenum in FD group with normal gastric emptying did not differ statistically from those in normal control group. Conclusion Gastric emptying dysfunction is closely related to NT, which can inhibit gastrointestinal motility and delay gastric emptying. Thus, NT is important in the pathogenesis of FD.