摘要
采用高效液相色谱法测定人血清中胺碘酮的浓度 ,色谱柱为ShimpackC1 8柱 (1 5 0mm× 6mm ,5 μm)。流动相为甲醇 -水 -二乙胺 (75 0∶2 5 0∶5 ) (醋酸调pH值 5 5 )。流速为 1ml·min- 1 ,检测波长为 2 42nm。测得胺碘酮的平均回收率为 1 0 2 3 % ,RSD为 6 7% ,方法快速 。
A HPLC method has been established for the determination of amiodarone in serum. The column was Shimpack C 18 (150mm×6mm, 5μm). The mobile phase was methanol-water-diethylamine (750∶250∶5) (pH value was adjusted to 5 5 by acetic acid). The detection wavelength was 242nm. The average recovery was 102 3% and the RSD was 6 7%. This method is rapid and simple.
出处
《中国药事》
CAS
2003年第5期319-320,共2页
Chinese Pharmaceutical Affairs
