不同种EP方案治疗老年人非小细胞肺癌的临床观察

Clinic Observation of Different EP Regimens in Treatment ofElderly Patients with Non-Small Cell Lung Cancer

目的 :探讨不同剂量及途径用药的EP方案治疗非小细胞肺癌的疗效和不良反应。方法 :1999年 1月～ 2 0 0 2年 1月将 14 3例非小细胞肺癌患者随机分为A(35例 )、B(36例 )、C(37例 )、D(35例 ) 4组 ,分别使用静脉小剂量滴注顺铂加口服足叶乙甙或静脉滴注足叶乙甙 ,以及静脉大剂量滴注顺铂加口服足叶乙甙或静脉滴注足叶乙甙四种EP方案治疗。结果 :4例EP方案的有效率分别为 4 0 .0 % (14 / 35 )、38.9% (14 / 36 )、4 0 .5 % (15 / 37)、4 2 .9% (15 /35 ) ;中位缓解期分别为 3.8月、4月、3.7月、3.4月。A组有白细胞下降、恶心、呕吐及脱发等不良反应最少 ,D组最多。结论 :静脉小剂量滴注顺铂口服足叶乙甙组成的EP方案简便、不良反应少 ,而且经济 。

Objective:To evaluate the efficacy and toxicity of different EP regimens in treatment of elderly patients with non small cell lung cancer.Methods:Between January 1999 and January 2002,143 cases of non small cell lung cancer were randomized into four groups:group A(35 cases),B(36 cases),C(37 cases),and D(35 cases).The patients in the four group were treated with EP regimen of different dosage and port of administration.Results:The response rates in groups A,B,C,and D were 40.0%,38.9%,40.5%,and 42.9%,respectively.The median remissive times were 3.8, 4, 3.7, and 3.4 months, respectively.The incidence of leukopenia, nausea, vomiting,and alpecia of the group A was the lowest,while was the highest in group D.Conclusion:EP regimen of intravenous dripping low dose cisplatin with p.o etoposide for patients with non small cell lung cancer would be an active and practical regimen with relatively low toxicity. It is especially suitable for elderly patients with non small cell lung cancer.