胆囊癌组织微血管密度变化及其与预后的关系

Detection of microvessal density in gallbladder carcinoma

应用抗人 因子相关抗原 ( F8- RA)多克隆抗体、免疫组织化学 ( SABC)法 ,检测 40例胆囊癌组织中( MVD)的表达 ,并分析其与胆囊癌临床病理及预后的关系。结果发现 ,胆囊癌组织 MVD值与肿瘤浸润深度、临床病理分期、淋巴结转移密切相关 ,与病理类型及分化程度无关。MVD值较高者 ,中位生存期及 3年生存率显著降低。提示胆囊癌组织 MVD的增加 ,可促进病变的发展和转移 ;检测胆囊癌组织

The microvessel density(MVD) in gallbladder carcinoma of 40 cases was studied by immunohistochemical method,and the relationship between MVD and clinic pathology,prognosis was analysed.Result showed that the value of MVD was correlated with the depth of invasion,lymph node metastasis and clinic stage(P<0.01).The media survival time and 3-years survival rate was negative correlation with MVD.MVD may be regard as a prognostic factor in gallbladder carcinoma.