新诊断的Graves病患者肝功能测定的临床意义

Clinical significance of measuring liver function in newly d iagnosed patients with Graves' disease

目的 探讨新诊断的Graves病患者肝功能测定在临床上的意义。方法 对 111例新诊断的Graves病患者在用药前进行肝功能、肝炎抗体和肝胆B超检查 ,剔除合并肝胆疾病者 14例 ,然后按肝功能正常与否分为肝功能正常组 ( 4 6例 )和肝功能异常组 ( 5 1例 )。结果 入选的 97例新诊断的Graves病患者中 ,有 5 1例 ( 5 2 .6% )至少有一项肝生化指标异常。肝功能异常组的FT3和FT4显著高于肝功能正常组 (P均 <0 .0 0 1)。结论 5 2 .6%的新诊断Graves病患者可出现由甲亢本身引起的肝功能损害 。

Objective To evaluate the role of measuring l iver function in newly diagnosed patients with Graves' disease.Methods Liver function and the levels of hepatitis antibodies w ere measured and type B supersonic examination was given in 111 newly diagnosed patients with Graves' disease before treatment.14 cases of them with hepatobilia ry diseases were eliminated.The rest were divided into normal hepatic function(4 6 cases) and abnormal hepatic function group(51 cases) according to the result o f liver function.Results Among 97 newly diagnosed patients with Graves' disease chosen,51 patients(52.6%) had at least one abnormal liver laboratory indicator.T he levels of FT3 and FT4 in abnormal liver function group were significantly hig her than those in normal group( P <0.001).Conclusion Among the newly diagnosed patients with Graves' dis ease,the incidence of abnormal hepatic function resulted from hyperthyroidism i tself is 52.6%.Clinical symptoms of the patients with liver injury are often mor e severe.