脑梗死伴白质疏松患者的事件相关电位研究

Event-related Potentials in Patients of Cerebral Infarctio n with Leukoaraiosis

目的 探讨脑白质疏松与脑梗死患者认知功能障碍之间的关系。方法 检测 18例脑梗死伴白质疏松患者的事件相关电位 (ERP)并与单纯脑梗死组和正常对照组进行比较。结果 脑梗死伴白质疏松组分别与单纯脑梗死组、正常对照组进行比较 ,ERP的N2、P3潜伏期间有显著性差异 (P <0 .0 0 1) ,而N1、P2潜伏期及P3波幅间无显著性差异 (P >0 .0 5 )。单纯脑梗死组与正常对照组进行比较则ERP的N1、P2、N2、P3潜伏期及P3波幅间均无显著性差异 (P >0 .0 5 )。结论 白质疏松与脑梗死患者认知功能障碍有关 。

Objective To study the relation between leuko ar aiosis(LA) and the disorder of cognitive function of patients with cerebral inf arction.Methods An auditory discrimination paradigm was employed to eli cit event related potentials(ERP) in 18 patients of cerebral infarction with le ukoaraiosis (LA).and compared to patients of cerebral infarction without leukoar aiosis and age matched healthy controls.Results The results indicated that the latencies of N2,P3 in th e patients of cerebral infarction with leukoaraiosis were significantly prolonge d( P <0.001),whereas the latencies of N1,P2 and P3 amplitude showed no signifi cant difference( P >0.05) as compared to patients of cerebral infarction witho ut leukoaraiosis and age matched healthy controls.But the latencies of N1,P2,N2 ,P3 and P3 amplitude in patients of cerebral infarction without leukoaraiosis sh owed no significant difference as compared to age-matched healthy controls.Conclusion It was suggested that disorder of cognitive function of patients with cerebral infarction has relation with leukoaraiosis,and that E RP may provide a sensitive cognitive function test for the patients of cerebral infarction with leukoaraiosis .