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Ⅰ、Ⅲ型前胶原端肽和血管紧张素Ⅱ与心功能不全的关系 被引量:3

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摘要 目的 探讨Ⅰ型前胶原羧基端肽 (PⅠCP)、Ⅲ型前胶原氨基端肽 (PⅢNP)、血管紧张素Ⅱ (AⅡ )、醛固酮 (ALD)与心功能不全的关系。方法 采用ELISA法、放射免疫法对 5 1例充血性心力衰竭 (CHF)患者 (心功能Ⅱ级 14例 ,Ⅲ级 2 0例 ,Ⅳ级 17例 )血中PⅠCP、PⅢNP、AⅡ及ALD水平进行检测 ,并与 2 6名正常人 (对照组 )进行对比分析。结果 CHF患者血中PICP、PⅢNP、AⅡ及ALD水平较对照组明显增高 (P <0 .0 0 1) ,与病情的严重程度一致。相关分析表明 ,PⅠCP、PⅢNP分别与AⅡ、ALD呈正相关关系 (P <0 .0 5~ 0 .0 0 1)。结论 PⅠCP、PⅢNP可作为监测CHF患者心肌纤维化及进程的间接指标 。
出处 《临床内科杂志》 CAS 北大核心 2003年第5期263-264,共2页 Journal of Clinical Internal Medicine
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