抗凝剂与全血比例对肝炎患者PTA测定值的影响

Impact of Ratio of Anticoagulant/Blood on Examining PTA in Patients with Hepatitis

目的观察肝炎患者中抗凝剂与全血比例对PTA测定值的影响。方法36例病毒性肝炎患者血液与抗凝剂分别按9:1和6:1混合,测定凝血酶原活动度(PTA)。结果在不同临床类型的肝炎患者中,抗凝剂与全血比例为1:9时测出的PTA与抗凝剂与全血比例为1:6时测出的PTA值有显著性差异。在轻度慢性肝炎组分别为95±15.2和54±5.6;在中、重度慢性肝炎组分别为54±6.1和37±3.5;在重型肝炎组分别为28±6.4和18±7.2。结论抗凝剂与全血比例为1:9时测出的PTA值比1:6时测出的PTA值为高,与临床符合率更好。

Objective To investigate the impact of ratio of anticoagulant/blood on examining prothrombin activity (PTA) in patients with hepatitis. Methods Blood samples were taken from 36 cases with hepatitis and PTA was examined under different experimental condition, in which anticoagulant and the blood were mixed in ratio 1:9 and 1:6. Results In all patients with clinical symptom of hepatitis,significant difference with PTA were observed when comparing the group at the ratio of 1:9 with that of 1:6. Comparing two groups of ration 1:9 and 1:6, the PTA were 95 ± 15.2 and 54 ± 5.6, respectively, in mild chronic hepatitis group, and 54±6.1,37±3.5, respectively, in moderate and severe chronic hepatitis group, while the PTA were 28± 6.4,18 ±7.2,respectively,in grave hepatitis groups. Conclusion Under the experimental condition,in which the ratio of anticoagulant/ blood is 1:9, the sensitivity of PTA test is higher, and the PTA value is more coincidental with clinical type of hepatitis.