卡氏肺孢子虫病动物模型的研究

Study on Animal Model of Pneumocystis Carinii Pneumonia

将48只昆明远交系小白鼠分成4组,分别给予正常蛋白食物(约含蛋白质25％)+可的松类药物+抗生素和低蛋白食物(约含蛋白质8％)+可的松类药物十抗生素处理并设相应对照组。结果:接受低蛋白饲养的小鼠,其体重的变化及卡氏肺孢予虫感染率与接受正常蛋白饲养的小鼠无差异。未给予激素的对照组小鼠无一感染卡氏肺孢子虫。提示:正常蛋白食物饲养+足量激素诱发动物卡氏肺孢了虫肺炎的方法较通常使用的低蛋白饲养+激素的方法优越。

Forty-eight Kunming mice was divided into four groups.Two experimental groups were given reg- ular-protein(25％)diet+glucocorticoid+antibitic and low-protein(8％)diet+glucocorticoid+an- tibiotic respectively.Others were not given glucocorticoid as the controls of them,Between two experi- mental groups,the mean weight of mice and the rate of p.carinii infection showed non-significant dif- ferences.None of the control mice had P.carinii infection.The results suggest that the regemin of regu- lar-protein(25％)diet with enough glucocorticoid is superior to that of low-protein(8％)diet with glacocorticoid to induce P.carinii infection,although the later is usually adopted.