摘要
采用抗T淋巴细胞单克隆抗体(T_3、T_4、及 T_)及PAP技术对19例(21例次)SLE患者皮损中T淋巴细胞亚群进行了检测。结果表明:活动期与非活动期 SLE 患者皮损中 T 细胞各亚群均较对照组明显增高,T_4/T_比值降低,有显著性意义;同一组织中,与 T_4^+细胞相比,多显示 T_^+占优势;除真皮层外,T_^+细胞还浸润至表皮层。提示 SLE 皮肤损害与局部 T 淋巴细胞浸润有着一定的关系。本观察还发现,活动期与非活动期患者相比,皮损中 T 淋巴细胞各亚群及 T_4/T_比值均无显著性差异,推测皮损中炎性细胞浸润的程度与全身病情轻重关系不大,而与皮肤损害程度有关。
T cell subsets in lesional skins from 19 patients with systemic lupus erythematosus(SLE)were tested by actechinque of antic T cell monoclonal antibodes and peroxidase antiperoxi dase(PAP).The results showed that the number of T cells(T_3^+,T_4^+and T_8^+)in lesional skin of patients with SLE in- creased and the ratio of T_4/T_8 decreased markedly;that within the same lesional skin,T_8^+ cell was predminant compared with T_4^+ cell.which infiltrated epiderm besides derma,it suggested that the cuta- neous lesion was related to T lymphotic infiltration.Our studies also showed that there was no differ- ence between active and inactive patients with SLE in T cell subsets the ratio of T_4/T_8,suggesting that the extent of infiltration of inflammatory cells was not markedly related to the extent of the whole dis- ease.but to the extent of the lesional skm.
