大肠癌与大肠血吸虫病的AgNOR及P_(21)^(ras)比较研究

Comparative Study of AgNOR and P_(21)^(ras) in Carcinoma and Schistosomiasis of Large Bowel

对25例大肠癌、20例大肠血吸虫病及20例正常大肠粘膜进行AgNOR 计数及 P_(21)~表达观察。结果显示大肠癌组与大肠血吸虫病组及正常粘膜组比较差异具有高度显著性,而大肠血吸虫病组与正常组比较差异无显著性,说明大肠血吸虫病与大肠癌关系不甚密切,作为癌前病变的意义远非大肠腺瘤重要,慢性大肠血吸虫病不应视为癌前性疾病。

Study of count AgNOR and expression of P_(21)^(?) in 25 cases of the carcinoma of large intestine and 20 cases of the schistosomiasis of large intestine,as well as in 20 cases of normal large intestinal mu- cosa,shows a significant elevation in large intestinal carcinoma when compared with schistosomiasis and normal mucosa of large intestine.However,the difference is not significant between schistosomia- sis and normal large intestinal mucosa.These results suggest that there is no relation between schistoso- miasis and carcinoma of large intestine.Chronic schistosomiasis of large intestine is not a precancerous disease.