摘要
制备了羟乙基乙二胺三甲撑膦酸(HEDTMP)的153Sm标记物,研究了标记物的标记条件、体外稳定性、化学计量组成、兔SPECT骨扫描及小鼠体内分布。结果表明,弱碱性介质、高配体量有助于标记物的形成,中性、弱碱性介质和高配体量有利于标记物的稳定,实验条件制备的标记物的化学计量组成为153Sm HEDTMP=1 1,兔骨显像和小鼠体内分布表明标记物主要由动物骨骼系统摄取,是非常有希望的骨肿瘤缓解治疗剂。
HEDTMP (N- (2- hydroxyethyl) ethlenediamine-1,1,2-tri(methylene phosphonic acid)) was synthesized and labeled with 153Sm. The labelling condition, stability, molar ratio of 153Sm to HEDTMP, rabbit bone imaging and biodistribution of 153Sm -EDTMP in mice were investigated. The results showed that weak basic media and high concentration ligand were favorable to form 153Sm-HEDTMP,and neutral or weak basic media increased stability of 153Sm-HEDTMP. The higher the concentration of HEDTMP, the more stable the labelled complex. The results also indicated that the chemical mole ratio of 153Sm-HEDTMP was 153Sm﹕HEDTMP=1﹕1 and the skeleton uptake of 153Sm-HEDTMP was high ((25.68 1.22)ID%/g bone at 3h and (16.56 1.01)ID%/g bone at 48h post-injection) while the nontarget tissue uptake is low. Therefore, 153Sm-HEDTMP may be a promising bone tumor therapeutic agent.
出处
《核技术》
CAS
CSCD
北大核心
2003年第5期388-392,共5页
Nuclear Techniques
基金
国家自然科学基金(299771027)资助
