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中药SSY-B2对隔海马穹窿伞切断致大鼠学习记忆障碍的改善作用 被引量:9

Effect of SSY-B2 on improvement of learning/memory function of rats with bilateral fornix/fimbria transection
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摘要 目的观察中药提取物SSY B2对穹窿伞切断致大鼠学习记忆障碍的改善作用。方法成年雄性SD大鼠随机分为 6组 :假手术组、模型组、阳性对照药脑复康治疗组、SSY B2小剂量治疗组 (1 5 g生药 /kg) ,SSY B2中剂量治疗组 (3g生药 /kg) ,SSY B2大剂量治疗组 (6g生药 /kg)。术前 0 5— 1小时灌胃给予试验用药直到行为学测试结束。手术后第 4周开始进行Morris水迷宫测试 ,记录游出时间 ;第 6周进行通道式水迷宫测试记录游出时间和错误次数。结果小、中剂量SSY B2治疗能缩短大鼠的游出时间或减少错误次数。结论SSY B2具有改善穹窿伞切断所致的空间学习记忆障碍的作用。 ObjectiveTo study the effect of SSY-B2 on improvement of learning/memory function of rats with bilateral fornix/fimbria transection.MethodsMale adult SD rats were divided randomly into 6 groups as sham group,model group,positive control agent piracetam group, SSY-B2 low(1.5g crude drug/kg), medium(3g crude drug/kg)and high dosage (6g crude drug/kg)group. Half to 1 hour before operation, water or drugs were fed introgastrically to each group respectively. From the fourth week, Morris water maze and tunnel water maze tests were used. Escape latency of rats in Morris test, escape latency and errors in tunnel test were recorded.ResultsIn both Morris test and tunnel water maze test, low dosage and medium of SSY-B2 markedly shorten the escape latency or reduced the errors.ConclusionsSSY-B2 can ameliorate spatial learning/memory dysfunction produced by fornix/fimbria transection. Functional compensation in other neural structure other than regeneration of the septohippocampal pathway is considered to be responsible for the effects.
出处 《中国康复理论与实践》 CSCD 2003年第5期286-288,共3页 Chinese Journal of Rehabilitation Theory and Practice
基金 首都二四八重大创新工程 (生物医药领域 )项目 (No.H0 1 0 2 1 0 1 30 1 1 3) 国家重点基础研究发展计划"973"项目 (No.2 0 0 0 0 570 1 0 )
关键词 中药 SSY-B2 学习记忆障碍 康复 traditional Chinese medicine SSY-B2 learning/memory impairment rehabilitation
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  • 1陈立嘉 周淑梅.中枢神经系统损伤后功能恢复的理论[A].缪鸿石.康复医学理论与实践[C].上海:上海科学技术出版社,2000.49-100.
  • 2刘燕强,顾景范.学习和记忆的神经生化学机制的研究概况[J].生理科学进展,1998,29(3):203-208. 被引量:27
  • 3隋建峰,熊鹰,张长城,熊雄.胎脑提取液对隔─海马通路损伤大鼠学习和记忆的影响[J].第三军医大学学报,1995,17(2):156-157. 被引量:1
  • 4舒斯云,包蓉,包新民,郑兆聪,牛东滨.大鼠纹状体边缘区与Meynert氏基底核的突触联系及其与学习记忆功能的关系——WGA-HRP束路追踪法、电镜法和行为实验法研究[J].中国组织化学与细胞化学杂志,1998,7(1):2-12. 被引量:24
  • 5Spruijt B, Pitsikas N, Algeri S, et al. Org2766 improves performance of rats with unilateral lesions in the fimbria fornix in a spatial learning task[J]. Brain Res, 1990, 527:192-197.
  • 6Aggleton JP, Keith AB, Rawlins JN, et al. Removal of the hippocampus and transection of the fornix produce comparable deficits on delayed non-matching to position by rats[J]. Behav Brain Res,1992,52(1) : 61-71.
  • 7Sutherland RJ;Rodriguez AJ. The role of the fornix/fimbria and some related subcortical structures in place learning and memory[J]. Behav Brain Res, 1989,32 (3) : 265-277.
  • 8Danks AM, Oestreicher AB, Spruijt BM, et al. Behavioral and anatomical consequences of unilateral fornix lesions and the administration of nimodipine [J]. Brain Res, 1991,557 (1-2) : 308-312.
  • 9Weskamp G,Gasser UE,Dravid AR,et al. Fimbria-fornix lesion increases nerve growth factor content in adult rat septum and hippocampus[J]. Neurosci Lett, 1986,70(1) : 121-126.

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