摘要
目的观察中药提取物SSY B2对穹窿伞切断致大鼠学习记忆障碍的改善作用。方法成年雄性SD大鼠随机分为 6组 :假手术组、模型组、阳性对照药脑复康治疗组、SSY B2小剂量治疗组 (1 5 g生药 /kg) ,SSY B2中剂量治疗组 (3g生药 /kg) ,SSY B2大剂量治疗组 (6g生药 /kg)。术前 0 5— 1小时灌胃给予试验用药直到行为学测试结束。手术后第 4周开始进行Morris水迷宫测试 ,记录游出时间 ;第 6周进行通道式水迷宫测试记录游出时间和错误次数。结果小、中剂量SSY B2治疗能缩短大鼠的游出时间或减少错误次数。结论SSY B2具有改善穹窿伞切断所致的空间学习记忆障碍的作用。
ObjectiveTo study the effect of SSY-B2 on improvement of learning/memory function of rats with bilateral fornix/fimbria transection.MethodsMale adult SD rats were divided randomly into 6 groups as sham group,model group,positive control agent piracetam group, SSY-B2 low(1.5g crude drug/kg), medium(3g crude drug/kg)and high dosage (6g crude drug/kg)group. Half to 1 hour before operation, water or drugs were fed introgastrically to each group respectively. From the fourth week, Morris water maze and tunnel water maze tests were used. Escape latency of rats in Morris test, escape latency and errors in tunnel test were recorded.ResultsIn both Morris test and tunnel water maze test, low dosage and medium of SSY-B2 markedly shorten the escape latency or reduced the errors.ConclusionsSSY-B2 can ameliorate spatial learning/memory dysfunction produced by fornix/fimbria transection. Functional compensation in other neural structure other than regeneration of the septohippocampal pathway is considered to be responsible for the effects.
出处
《中国康复理论与实践》
CSCD
2003年第5期286-288,共3页
Chinese Journal of Rehabilitation Theory and Practice
基金
首都二四八重大创新工程 (生物医药领域 )项目 (No.H0 1 0 2 1 0 1 30 1 1 3)
国家重点基础研究发展计划"973"项目 (No.2 0 0 0 0 570 1 0 )
关键词
中药
SSY-B2
学习记忆障碍
康复
traditional Chinese medicine
SSY-B2
learning/memory impairment
rehabilitation