丁丙诺啡含片对晚期癌症患者镇痛效果的临床研究

Buprenorphine Buccal-Analgesic Effects in Advanced Cancer

目的 研究丁丙诺啡含片的临床镇痛效果。方法 与丁丙诺啡针剂比较 ,将 60例晚期癌症病人随机分为两组 ,对两组各 3 0例进行双模拟双盲试验。结果 该药两种剂型的镇痛强度和疼痛缓解度均无统计学差异 (P >0 0 5 ) ;不良反应中恶心呕吐片剂小于针剂 (P <0 0 5 ) ,恶心、头晕、出汗和嗜睡无统计学差异 (P >0 0 5 ) ;片剂与针剂对心率、呼吸频率、血压均无明显影响。结论 丁丙诺啡含片为良好的强效镇痛药 ,服用携带方便 ,值得临床推广使用 。

Objective To study the clinical effects of buprenorphine buccal that is a long-action opioid analgesic. Method The clinical analgesic effects of subligually buprenorphine had been randomly compared with the buprenorphine intramuscularly in sixty cases patients with advanced cancer, there were 30 cases each group. Results The difference of the percentage of pain relief was not statistically difference between thetwo groups(P>0 05).buprenorphine buccal produced less nausea and vomiting than those in the other route(P<0 05).The incidence of dizziness,sweating and lethargy was not different between the two groups(P>0 05).The changes of the vital signs in two groups were not clinically important. Conclusions The study indicates that the analgesia effects of buprenorphine sublingual administered is same as intramuscular buprenorphine,but the buprenorphine buccal is more convenient.However,the drug dependence terdency should be monitored.