潘托拉唑预防和治疗腹部大手术后应激性溃疡

Study of Prevention and Treatment Stress Ulcer by Pantoprazole after Abdominal Surgery

目的 探讨潘托拉唑预防和治疗腹部大手术后应激性溃疡出血的疗效及安全性。方法 46例腹部大手术病人随机分为潘托拉唑组和雷尼替丁组 ,围手术期分别应用潘托拉唑及雷尼替丁预防治疗 ,观察术后 2组病人的胃液pH值及有无消化道出血的临床表现 ,并将手术后发生应激性溃疡消化道明显出血的 12例病人随机分为潘托拉唑组和洛赛克组 ,分别应用潘托拉唑和洛赛克治疗 ,观察其疗效。结果 潘托拉唑组术后胃液的pH值明显高于雷尼替丁组 (P <0 0 5 ) ,潘托拉唑组 2 4例病人中术后消化道出血的发生率为 0 ,雷尼替丁组术后应激性溃疡发生率为 13 6% (3 /2 2 )。 12例应激性溃疡溃疡病人 ,均获治愈 ,但潘托拉唑组临床止血的时间较洛赛克组明显缩短。结论 潘托拉唑对腹部大手术后应激性溃疡具有良好的预防和治疗作用 ,其预防应激性溃疡的作用优于雷尼替丁 。

Objective To study the prevention and treatment of stress ulcer after abdominal surgery by pantoprazole.Methods 46 cases with standing abdominal surgery were randomly divided into 2 groups;Used ranitidine or pantoprazole respectively for prevention of stress ulcer in perioperation. Furthermore, there were 12 alimentary hemorragic patients with stress ulcer treated by omerprazole or pantoprazole respectively.Results The pH of gastric juice in pantoprazole group was higher than that in ranitidine group,the morbidity of stress ulcer in pantoprazole group was lower than in ranitidine group. All of 12 stress ulcer cases were cured,and the cured time in pantoprazole group was shorter than in omerpazole group.Conclusions Pantoprazole is a good agent to prevent and treat the stress ulcer after abdomimd surgery.