摘要
目的 研究野生山葡萄多酚类物质 (PVA)对小鼠组织的抗氧化作用。方法 采用TBA法、NBT法和荧光法 ,分别测定小鼠心、肝、肾、脑组织中MDA含量、SOD活性及脂褐质含量。结果 PVA( 2 0 0、40 0mg/kg·d× 30d)显著降低 ,以上各组织MDA及脂褐质的含量 (P <0 0 5 ) ,PVA( 40 0mg/kg·d× 30d)极显著提高心、脑组织SOD活性和降低心、脑组织脂褐质及MDA含量 (P <0 0 1)。结论 PVA能有效地提高机体组织抗氧化能力 ,防止组织脂质过氧化损伤。
Objective To study the anti-oxidative action of PVA on the tissues of mice.Methods Contents of malon-dialdehyde(MDA),superoxide dismutase(SOD) and lipofuscin in the heart,liver,brain and kidney of mice were measured using TBA,NBT and fluorescent technique respectively.Results PVA(200,400?mg/kg·d×30?d)could decrease significantly the content of MDA and the content of lipofuscin in all tissues(P<0.05).PVA(400?mg/kg·d×30?d)could increase significantly the activity of SOD and decrease significantly the content of lipofuscin and MDA in heart,brain of mice.Conclusion PVA could increase the anti-oxidative action in vivo significantly and prevent lipid peroxidation damages in tissues.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2003年第5期569-570,共2页
Chinese Journal of Public Health
基金
吉林市科技发展计划项目 (2 0 0 2 .30 0 )
关键词
野生山葡萄多酚类物质
超氧化物歧化酶
丙二醛
脂褐质
抗氧化
plyphenols of vitis amurensis rupr
superoxides dismutase
malondialdehyde
lipofuscin
anti-oxidation
