麦胚提取物对辐射损伤修复的实验研究

Study on repairing function of wheat embryo extracts(WEE) on radiation damage

目的 研究麦胚提取物对小鼠辐射损伤修复的调节和保护作用。方法 采用辐射前或辐射同时饲喂一定量的麦胚提取物 ,观察小鼠经X射线一次性全身照射后的临床症状、30d存活率、骨髓微核率、外周血白细胞总数在不同时间的变化。结果 与对照组 (单纯照射 )比较 ,饲喂麦胚提取物可使小鼠的头面部皮肤、小肠黏膜、肾脏损伤症状得到明显改善 ;30d存活率为 86 17%(P <0 0 1) ,提高存活率 41 79%,保护系数为 1 72 ;骨髓微核率 4 6 2‰ ;比对照组 ( 12 14‰ )降低 (P <0 0 1) ;外周血白细胞总数在 7,13 ,2 0 ,30d均显著回升 (P <0 0 5 ,P <0 0 1,P <0 0 1,P <0 0 1)。结论 麦胚提取物对小鼠辐射损伤修复有一定程度的调节和保护作用 ,对于辅助肿瘤放射治疗具有重要意义。

Objective To study repairing and adjusting function of WEE on radiation damage of mice.Methods The mice's whole bodies were irradiated with a x-ray source and were divided into experimental groups of fed WEE for 10 days before due date or same time but the control was not irradiated only.General symptoms,and 30-day survival rate,and marrow micronucleus rate,and leukocytes to varying time were observed.Results Compared with the control,the symptoms of experimental groups were remarkable better in damaged skin of head and face,intestine mucosae,kidney,etc.30-day survival rate was 86.17% which was raised 41.79%.Porective coefficient was 1.72 and marrow micronucleus rate 4.62‰ lower than the control (12.14‰,P<0.01).The leukocytes of experimental mice were picked up rapidly on 7,13,20,30 days and were different from the control(P<0.05,P<0.01,P<0.01,P<0.01).Conclusion WEE can adjust bio-activity for repairing irradiated damages,and might play an important role in radiotherapy of tumor.