颅脑外伤合并水、电解质紊乱“个体化”治疗的临床研究

The Clinical Study of Individual Treatments to the Disordersof Water and Electrolytes Due to Cerebral trauma

目的探讨颅脑外伤合并水、电解质紊乱“个体化”治疗的疗效。方法将我院收治的100例颅脑外伤患者,随机分为2组(n=50)。对照组按常规治疗,限制水、电解质的摄入;研究组依照“个体化”治疗方案补充输液和电解质。观察患者治疗前和治疗3天后血液中渗透压和电解质(钾、钙、钠、镁)变化、生存率和住院天数。结果3天后研究组多数病例的血浆渗透压及钠钾均处于正常范围,疗效明显优于对照组(P<0.05),而两者血浆钙镁、病死率和住院天数则无统计学意义。结论“个体化”治疗方案在纠正颅脑外伤合并水、电解质(钠、钾)紊乱方面,疗效确切,明显优于常规方法。

Objective To study the effects of individual treatments to disorders of water andelectrolytes due to cerebral trauma. Methods From Sep.1999 to Jul.2002, One hundred of patients wererandomly divided into 2 groups (n=50), Control group was subjected to traditional treatment (definedinfusion and salt), Study group was treated with individual therapies, supplied with infusion and saltaccording to the needs of patients . The serum osmotic pressure and concentration of electrolytes(Na+,k+, Ca2+,Mg2+) were examined before and 3 days after therapy in both groups,and the mortality rate andhospital days.Result After 3 days of treatment, most of patients in Study group were normal in serumosmotic pressure, Na+ and K+, and significantly different from control group (P<0.005). But other datashowed the statistical difference between 2 groups. Conclusions The individual treatment is efficientto correct the disorders of water and electrolytes(Na+,K+)due to cerebral trauma, and prominent to thetraditional therapy.