三种蝮蛇抗栓酶的毒性及性质的实验研究

Expermental Study of the Toxicity and Characteristic of Antithombotic Esterases from Three Species of Pit Viper

目的:对三种蝮蛇抗栓梅的毒性及其性质进行实验研究。方法:小白鼠尾静脉注射急性毒性实验法和家兔亚急性毒性实验法。结果:三种蝮蛇抗栓酶的毒性强度用LD_50表示,分别是,蛇岛蝮蛇抗栓酶为1.68±0.35u/kg,东北陆生白眉蝮蛇抗栓酶为5.223±0.61u/kg,浙江蝮蛇抗栓酶为1.94±0.15u/kg。对家兔亚急性毒性实验表明,对血细胞、肝及肾功能、脏器等无明显影响。

The toxicity and characteristic of antithrombotic esterases from three different species of pit viper were studied.The LD_50's of antithrombotic esterases from Agkistrodon Shedaoensis (Zhao),A.halys(pallas)and A.halys brevicaudus(Stejeger)were 1.68±0.53u/kg,1. 94±0.15u/kg and 5.23±0.61u/kg,respectively.The results of short—term toxicity test on rab- bits showed that none of the three antithrombotie esterases had remarkable toxic effect on blood cells and functions of liver and kidney.