摘要
目的:考察影响甲硝唑片溶出度的因素。方法:压片前分别按5种不同比例加羧甲基淀粉钠(CMS—Na)及硬脂酸镁,混匀,压片,测其溶出度:分别以87℃与50℃的淀粉作粘合剂制软材,压片,测其溶出度;分别以不同大小、不同硬度的颗粒压片,测其溶出度:同批颗粒分别制成直径8,9,10mm三种规格的片剂,测其溶出度。结果:CMS—Na能显著提高甲硝唑片溶出度。
To investigate the factors influencing the dissolution of metronidazole tablet. Methods:CMS—Na and magnesium stearate were added with five different ratios before tablet- ting,respectively,mixed equally and tabletted,then the dissolution was determined;the soft mate- rials were made with 87 and 50 of starch as adhesion agent,and respectively,tabletting,then the dissolution was determined,tablets were expressed with the grains of different magnitude and dif- ferent hardness,then the dissolution were determined same group of grains were expressed into three tablets,of which diameters were 8,9,10ram respectively.Results:CMS—Na could obviously increase the dissolution of metronidazole tablet.
出处
《黑龙江医药》
CAS
2003年第3期187-188,共2页
Heilongjiang Medicine journal