肺炎衣原体感染与急性心肌梗死的相关性研究

A Study on the Correlation between the Infection of Chlamydozoon pneumoniae and Acute Myocardial infarction

目的:研究肺炎衣原体(CP)感染与急性心肌梗死(AMI)以及与其发病机理有关的血浆纤维蛋白原(Fg)、血栓素B_2(TXB_2)及血脂的相关性。方法:用ELISA法对急性心肌梗死急性期组(AMI_A)、急性心肌梗死恢复期组(AMI_R)、陈旧性心肌梗死组(OMI)、正常对照组(N)分别进行血清CP特异性IgG、IgM抗体检测,并检测各组的血Fg、TXB_2、血脂(TC、TG、LDL、HDL)水平。结果:AMI_A组、AMI_R组、OMI组IgG阳性率均高于N组,差异显著(P=0.03);AMI_A组IgM阳性率显著高于其余3组。IgG阳性与心肌梗死的出现相关,校正了各影响因素后危险度为2.0。IgG与Fg、TXB_2、TC、LDL正相关;IgM与TG、TXB_2正相关。结论:(1)CP感染与冠心病心肌梗死有关,且急性感染与急性心肌梗死发作有关,很可能是后者的一个促发因素;(2)CP感染与Fg、TXB_2和血脂之间存在不同程度的相关性。

Objective: To study the correlation between the Infection of Chlamydozoon pneumoniae (Cp) and Acute Myocardial infarction (AMI) , and the correlation between Cp and some indexes in relation to AMI including fibrinogen (Fg), thromboxane B2 ( TXB2 ) , and Lipids (TG, TC, LDL, HDL). Methods: Specific antibodies of IgG and IgM against Cp were determined in AMI patients at a-cute stage ( AMIA) , and restoration stage ( AMIR) , and in patients of old myocardial infarction ( OMI) and in normal people (N) with ELISA; The levels of Fg, TXB2, and lipids in serum were determined in all the groups. Results: IgG - positive rates in all the patient groups were significantly different from that in N group; IgM - positive rates in AMIA group is statistically different from those in the rest groups. The positive rate of IgG related to the occurrence of myocardial infarction. After correcting the effecting factors, the OR was 2.0. There were positive corelations between level of IgG and levels of Fg, TXB2, TC, and LDL, and the IgM level and TXB2, TG. Conclusions: 1) Cp infection relates to AMI, and the acute Cp infection relates to the occurring of AMI too. The latter one might be the inducing factor; 2) The correlation of various extent occurs between Cp infection and the levels of Fg, TXB2, and lipids.