3996例就诊及体检者幽门螺杆菌感染状况调查

An Investigation on HP Infection Status in Patients and Health Checking People in Hospital of Guiyang Medical Collage

目的:了解就诊及体检人群中幽门螺杆菌(HP)感染状况,探讨HP感染与相关疾病的关系。方法:采用金标免疫斑点法对3996人进行血清抗HP-IgG检测,还对其中2259人检测了抗HP-IgM。结果:(1)3996例中血清抗 HP-IgG总阳性率为76.0％;2259例 HP-IgM阳性率为41.2％。(2)HP-IgG、HP-IgM在性别间无显著性差异(P>0.05)。(3)年龄因素对HP-IgG和HP-IgM阳性率有显著(P<0.05)和极显著(P<0.001)影响。(4)HP感染存在家庭聚集倾向。(5)血清HP抗体阳性率升高的疾病:大于28 d小儿,消化系统疾病组较健康对照组,抗HP-IgM阳性率存在显著性差异(P<0.05);在成人中胃肠道疾病组与健康体检组抗HP-IgG阳性率相比,有极显著性差异(P<0.001);肝、胆、胰疾病、循环系统疾病组与健康体检组比较有显著性差异(P<0.05)。结论:HP感染与多种胃肠道、肝胆胰及循环系统疾病有关;人群初次感染始于婴幼儿期,且受家庭因素影响。

Objective:To investigate the incidence of Helicobacter pylori infection in both patients and health checking people in hospital of Guiyang medical collage, and the relationship between Hp infection and correlated diseases. Methods: Serum immunoglobulin G (IgG) and IgM antibodies were measured with dot immunogold filtration assay. IgG antibodies against H. pylori were assessed in 3 996 people among which serum antl-H. pylori(Hp) IgM of 2 259 people were also assessed. Results: ( 1) The positive rate of anti-Hp IgG in the 3 996 people was 76. 0% and anti-Hp IgM in the 2 259 people was 41.2% ; (2) There was no significant difference in seropositive rates between men and women (P >0. 05) ; (3) The seropositive rates were significantly different and highly significantly correlated with age in IgG (P <0. 05) and IgM (P <0. 001) respectively; (4) There was high clustering tendency of Hp infection in families; ( 5) Subjects with gastrointestinal diseases, compared with healthy controls, had a significantly higher seropositive rate of anti-Hp IgM in children (P < 0. 05) , and a much higher seropositive rate of anti-Hp IgG in adults (P <0. 001). Furthermore, the adults with liver, bile tract and pancreas diseases, and heart vascular diseases had significantly higher positive rate of anti-Hp IgG compared with the healthy adult controls (P <0. 05) . Conclusion: Hp infection is significantly correlated with many diseases in gastrointestinal tract, liver, bile tract, pancreas, and heart vascular. The infection of Hp begins at infancy, and would be affected by family factors.