丙酸氟替卡松、沙丁胺醇吸入治疗儿童哮喘36例临床疗效观察

Aspirate treatment of fluticasone propionate and ablbuterol for children asthma:clinical observation of 36 cases

目的观察新一代的吸入性皮质激素丙酸氟替卡松(辅舒酮)及沙丁胺醇(万托林)治疗儿童哮喘的疗效及副作用。方法对36例哮喘患儿吸入治疗后的症状,PEFR变化以及副作用进行追踪动态观察和监测。结果该吸入治疗儿童哮喘临床疗效满意,能有效控制哮喘症状,改善肺功能。结论丙酸氟替卡松不仅具有很强的局部抗炎活性且能减少或避免糖皮质激素的全身性副作用。沙丁胺醇具有松驰气道平滑肌、增加粘膜纤毛的清洗功能、降低血管壁的通透性、调节肥大细胞及嗜碱细胞介质释放等作用。具有气道高反应性和改善气道炎症作用且使用安全。

Objective:To evaluate the effect and side effect of aspirated fluticasone and albuterol for child asthma.Methods:We not only observe the asthma symptom and drug bypass effect after treatment of fluticasone and albuterol for 36 asthma children as well as PEFR,but also run after these children for 3 months.Results:The therapy of fluticasone and albuterol is effective for children asthma.They can control episode of asthma and ameliorate pulmonary function.Conclusion:Fluticasone can inhibite inflammation but only has little bypass effect.Albuterol can not only relax and airway smooth muscle and increase cleaning function of mucosal cilia,but also reduce permaability of angiol parietis.It can adjust mastocyte and basophil to release cell medium.They all have airway hyperreactivity and can inhibite airway inflammation.Both of them are safe.