甘露醇治疗对急性肺损伤组织微血管床滞留中性粒细胞的影响

Effect of Melatonin Therapy on Neutrophils Being Sequestrated by Acute Injurious Lung Tissue

目的 :了解甘露醇对急性肺损伤组织微血管床滞留中性粒细胞 (PMN)的影响 ,进而探讨甘露醇对急性肺损伤组织微循环障碍治疗作用的机制。方法 :采用家兔内毒素性急性肺损伤模型 ,观察甘露醇治疗对急性肺损伤组织微血管床滞留核标记PMN显像的影响。结果 :甘露醇可显著加快标记PMN在肺组织中的消散速度 ,而速尿治疗组则未显示出此作用。结论 :甘露醇可减少急性肺损伤组织微血管床对PMN的滞留 ,从而改善损伤组织的微循环 。

Objective: To investigate the effect of melatonin on accumulation of polymorphonuclear neutrophils(PMNs) in microvessel of acute lung injurious(ALI) tissue,and assess the mechanisms of melatonin treatment to ALI.Method: The lung tissue of ALI rabbits model induced by endotoxin were examined by isotope lableled PMNs scanning technique to observate the curative effects of melatonin.Results: The disappearance of labeled PMNs in lung tissue were accelerated obviously by melatonin therapy,but were not affected by furosemide therapy.Conclusion: Melatonin could reduce the accumulation of PMN in acute injurious lung tissue and improve microcirculatory perfusion of injurious tissue.The melatonin of this function are in excess of the understanding of the routine solute diuretic effects.