摘要
目的:观察芪蛭皱肺胶囊对肺气肿模型豚鼠血T细胞CD_4/CD_8比值以及对小鼠巨噬细胞吞噬功能、免疫器官重量的影响。方法:用弹性蛋白酶复制豚鼠肺气肿模型。将豚鼠随机分为正常对照组、模型组及芪蛭皱肺胶囊治疗组,测定各组小鼠血CD_4/CD_8比值,同时观察该制剂对小鼠巨噬细胞及免疫器官功能的影响。结果:肺气肿豚鼠血CD_4/CD_8比值较正常组明显降低,经芪蛭皱肺胶囊治疗后CD_4/CD_8较模型组明显升高,并且芪蛭皱肺胶囊还可提高小鼠腹腔巨噬细胞的吞噬指数和吞噬百分率以及胸腺、脾脏指数。结论:芪蛭皱肺胶囊具有明显调节机体免疫功能的作用。
Objective : To observe the adjustment of Qizhizhoufei(QZZF) capsule on CD4/CD8 in the blood of pulmonary emphysema model cavy and mononuclear macrophage, immune organ of mice. Method : Copy pulmonary emphysema model cavy by spraying elastinase into cavies' lungs. Random-divide cavies into natural control experiment team, model team and treat teams of QZZF. To measure the ratio of CD4/CD8 in blood of cavies. Compared the phagocytic index of mononuclear macrophage and the immune organ weight of mice. Results : Compared with natural control experiment team, the ratio of CD4/CD8 of pulmonary emphysema model team are decreased obviously, but the ratio of CD4/CD8 in treated team with QZZF are increased obviously. The QZZF could significantly increase the phagocytic index of mononuclear macrophage and the immune organ weight of mice. Conclusion: QZZF has the effect of modulating the function of immunity.
出处
《中国中医药信息杂志》
CAS
CSCD
2003年第4期32-34,共3页
Chinese Journal of Information on Traditional Chinese Medicine
基金
甘肃省自然基金(ZS001-A23-061-Y)