冠心病与高血压病患者血浆中血栓前体蛋白的检测分析

The Clinical Study on Thrombus Precursor Protein Detecting Coronary Heart Disease and Essenial Hypertension.

目的:探讨血栓前体蛋白(TpP)与心肌肌钙蛋白I(CTn l)的检测对冠心病与高血压病患者早期诊断的临床意义。方法:冠心病组(CHD)26例,高血压病组(EH)30例和健康照组20例,采用ELISA法分别检测各组血浆TpP与CTn l含量。结果:CHD组,TpP值为7.26±1.97μg/ml,CTn 1值为2.94±2.51 ng/ml;EH组TpP值为3.70±1.2μg/ml,,CTn l值为1.34±1.31 ng/ml。CHD较对照组TpP值(3.14±0.96μg/ml)和CTn l值(0.67±0.21 ng/ml)均明显增高,差异呈显著性(P<0.01,P<0.05);而EH组的TpP值和CTn l值分别与对照组比较CTn l值差异呈显著性(P<0.05),TpP值差异不明显(P>0.05)。结论:应用TpP与CTn l联合检测血栓前状态可能对冠心病发展为心肌梗死有预示价值。

Objective:To explore the clinical value of thrombus precursor protein(TpP) and cardiac troponin 1 (CTn 1) in the patients with coronary heart disease(CHD) and essnial hypertension (EH) . Methods: Objects examined were composed of 3 groups 26 patients with CHD, 30 patients with EH and 20 hralthy people, TpP and CTn 1 concentration in three groups were measured by ELBA, and the results were done with statistics analysis. Results: The plasma level of TpP 7.26±1.97μg/ml and CTn 1 2.94±2.51ng/ml in CHD increased significandy than that in EH (P<0.01-0.05) , however, TpP 3.70± 1.20μg/ml concentration of EH did not increased singnifi-cantly than that (3.14±0.96ng/ml) in normal controls(P>0.05) ; CTn 1 level in plasma(1.34±1.31)ng/ml of cases with EH increased significandy that(0.67±0.21 ng/ml) in controls (P<0.05), Conclusion: TpP, together with CTn 1, can detect the pre-thromboticstate and prevent CHD from developing AMI, etc, and have a high predicative value.