^(32)磷胶体滑膜切除术治疗慢性血友病滑膜炎

Treatment of Chronic Hemophilic Synovitis with Colliodal (32)~P Chromic Phosphate

目的:观察^(32)磷胶体滑膜切除术治疗慢性血友病滑膜炎的疗效及安全性。方法:2001年至2002年我院对12例血友病患者的13个关节进行了^(32)磷胶体滑膜切除术。结果:经过3～13个月(中数时间11个月)的随诊观察,治疗后关节的平均出血次数由7.1±3.8次/6个月减少到3.2±2.5次/6个月(P<0.01),出血频率降低者占84.6％;69.2％的关节疼痛减轻;无1例出现明显并发症。结论:对于常规替代治疗无效的慢性血友病滑膜炎,^(32)磷胶体滑膜切除术是一种安全、有效的方法。

Objective; To observe the efficacy and savety of the traetment of chronic hemophilic synovitis with colliodal P chromic phosphate. Methods: Between 2001 and 2002, 13 radioactive synovectomies were performed in 12 hemophilic patients with chronic hemophilic synovitis. Results: After a median follow-up period of 11 months(3 to 13 months) , bleeding frequencies of the treated joints decreased from 7.1±3.8 times to 3.2±2.5 times per 6 months (P <0.01) . A definite diminution of hemarthoses was seen in 84.6% of the cases. 69.2% joints were pain free. No severe complications occurred. Conclusion: Isotopic synoviorthesis with colliodal P chromic phosphate is an effective and safe method for the treatment of chronic hemophilic synovitis in the patients who fail to the conventional therapy.