不孕女性支原体、衣原体感染与抗子宫内膜抗体的关系(附147例报告)

RELATIONSHIP BETWEEN ANTIENDOMETRIUM ANTI-BODY AND INFECTION OF UREAPLASMA UREALYTICUM,CHLAMYDIA TRANYDIA IN INFERTILE WOMEN

目的探讨不孕妇女支原体 (ureaplasmaurealyticum ,UU)、衣原体 (chlamydiatranydia ,CT)感染与抗子宫内膜抗体 (antiendometriumantibody ,AEMAb)的关系 ,以揭示抗子宫内膜抗体产生的可能机制。 方法选择不孕妇女 14 7人 ,其中原发不孕 79人 ,继发不孕 68人 ;并选择健康已孕妇女 70人作为对照组。取宫颈分泌物应用荧光定量聚合酶连反应行UU、CT的DNA检测 ,应用酶联免疫吸附法检测血清中AEMAb。结果不孕组UU、CT感染率、AEMAb阳性率与对照组比较均有显著性差异 (P 均 <0 .0 5 ) ;原发不孕与继发不孕患者UU、CT、AEMAb的阳性率相比无显著性差异 ;不孕组中AEMAb阳性患者与阴性患者的UU、CT感染率相比有显著性差异 (P <0 .0 5 )。结论UU、CT感染及AEMAb均可造成女性不孕 ,AEMAb的产生与UU、CT感染有关。

ObjectiveTo investigate the relationship between ureaplasma urealyticum(UU),chlamydia tranydia(CT) infection and antiendometrium anti body(AEMAb) in infertile women,and to find the possible mechanism of AEMAb's production.Methods147 infertile women were involved,79 women were primary infertility and 68 women were secondary infertility.70 health pregnant women were involved in control group.UU,CT of cervical secretion were detected with polymerase chain reaction(PCR).The serum AEMAb was detected with ELISA.ResultsThe statistical analysis showed that the positive rates of UU,CT,AEMAb in infertile group were higher than those in control group(P< 0.05 ).The positive rates of UU,CT,AEMAb showed no difference between primary and secondary infertility(P> 0.05 ).The positive rates of UU,CT in infertility patients of positive AEMAb were higher than those in negative patients(P< 0.05 ).ConclusionAEMAb and infection of UU,CT all can induce female infertilily.The production of AEMAb is related to the infection of UU,CT.