原发性高血压与脑卒中患者神经肽Y及内皮素和微循环的观察 降低高血压患者NPY、ET及改善微循环可减少脑卒中发生的建议

Plasma neuropeptide Y and endothelin levels and nailfold microcirculation in patients with essential hypertension and cerebral apoplexy

目的探讨血浆中神经肽Y(neuropeptideY,NPY)、内皮素(endothelin,ET)及甲襞微循环在原发性高血压和有原发性高血压史的脑卒中的发病过程中的变化及临床意义。方法采用放射免疫法ra-dioimmunoassay分别测定原发性高血压、脑梗死、脑出血患者和正常对照组血浆中NPY、ET的含量及使用微循环测定仪观察以上各组甲襞微循环变化。结果原发性高血压、脑梗死、脑出血患者与正常对照组比较,血浆中NPY、ET的含量增高,微循环异常积分增高(P均<0.01),但患者各组之间比较差异均无显著性(P>0.05)。结论原发性高血压、脑卒中患者存在神经内分泌异常,血管内皮细胞受损及微循环障碍,这些改变可能参与了这两类疾病的发病过程。

Aim To study the changes and clinical significance of plasma neuropeptide Y (NPY) and endothelin (ET) levels and nailfold microcirculation in patients with essential hypertension(EH) and hypertensive cerebral apoplexy.Methods Plasma NPY and ET levels and nailfold microcirculation were measured by radioimmunoassay(RIA) and apparatus respectively in controls and in patients with EH and cerebral infarction and cerebral hemorrhage.Results The levels of plasma NPY and ET and total integral value of nailfold microcirculation in patients with EH,cerebral infarction,cerebral hemorrhage were significantly higher than in those of the control group(P< 0.01),but no differences in plasma NPY and ET levels and nailfold microcirculation were found among three groups (P >0.05). Conclusion (1)There are abnormalism of neuroendocritic and of microcirculation and injury of vascular endothelium in patients with EH and cerebral apoplexy.(2)These changes may be involved in the development of hypertension and cerebral apoplexy. <P>