瘦素与中国新疆哈萨克族血压水平及相关因素的关系

The relationship among the serum leptin concentration, the level of blood pressure and relevant factors in Kazark of Xinjiang

目的瘦素与高血压的关系研究国内外不多且结果不一致,探讨血清瘦素浓度与新疆哈萨克族(简称哈族)的血压水平及性别、肥胖、体脂、血脂、和空腹胰岛素的关系。方法用放免法检测68例哈族高血压患者和124例哈族健康志愿者的血清瘦素浓度,同时检测血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、脂蛋白(a)［LP(a)］、空腹胰岛素(FINS)和体重指数(BMI)、体脂百分含量(Fat%)及腰围/臀围(WHR),并分析血清瘦素浓度与不同血压水平以及性别、BMI、Fat%、WHR和血脂、空腹胰岛素的关系。结果高血压组血清瘦素显著高于对照组(P<0.01),3级高血压血清瘦素显著高于2组高血压(P<0.05),2级高血压组血清瘦素显著高于1级高血压(P<0.05)。血清瘦素与SBP、DBP均呈直线正相关(P<0.01,P<0.05);女性瘦素显著高于男性(P<0.001),肥胖者瘦素显著高于非肥胖者(P<0.05);血清瘦素与TG呈直线正相关(P<0.05),而与TC、HDL-C、LDL-C及LP(a)无关;高血压组空腹胰岛素水平显著高于对照组(P<0.05),且瘦素与FINS水平呈正相关(P<0.01),与胰岛素敏感性指数(ISI)呈负相关(P<0.05)。结论血清瘦素与新疆哈族血压水平相关,与性别和TG有关,且与BMI、Fat%、TG及FINS呈正相关,与ISI呈负相关。

Aim To investigate the relationships among leptin, the level of blood pressure,gender,body mass index(BMI),lipid metabolism and fasting insulin(FINS) in Kazark of Xinjiang.Methods Leptin , the levels of serum total cholesterol(TC) ,the triglyceride(TG),the high density lipoprotein(HDL C) and the low density lipoprotein(LDL C),lipoprotein (a),BMI,waist/hip ratio(WHR) and Fat% were determined in 124 health persons of control group and 68 patients with essential hypertension.Serum leptin concentration and FINS were measured by radioimmunoassay.The correlation between leptin and other parameters were analyzed.Results Leptin levels in essential hypertension was found significantly higher than that in the control group(P< 0.05) .Leptin levels in grade 3 hypertension was significantly higher than that in grade 2 hypertension(P< 0.05) . Leptin levels in grade 2 hypertension was significantly higher than that in grade 1 hypertension(P< 0.05) .Leptin was remarkably correlated with SBP/DBP(P< 0.01/P< 0.05) .Leptin concentration in female was significantly higher than that in male(P< 0.001).Serum leptin level was elevated in obese subjects(P< 0.05).Serum leptin concentration was correlated to TG,BMI,Fat% and FINS , but not correlated to TC,HDL C,LDL C and Lp(a).The levels of FINS in hypertensive group were significantly higher than that in the control group(P< 0.05).FINS was positively correlated with the serum leptin level(P< 0.01) and ISI was negatively correlated with it(P< 0.05).Conclusion Serum leptin concentrations were directly related to blood pressure level,gender and TG in hypertensive patients in Kazark of Xinjiang , and were positively correlated with BMI,Fat% ,TG and FINS, and were negatively correlated with ISI.<P>